FACTS ABOUT PHENOBARBITAL INTERACTIONS REVEALED

Monitor Closely (one)phenobarbital will lower the level or effect of losartan by impacting hepatic/intestinal enzyme CYP3A4 metabolism.Advise patients to use an alternative way of contraception or perhaps a back-up process for the duration of coadministration, and to carry on back-up contraception for 28 days soon after discontinuing the strong CYP